Lipotoxicity相关论文
The research of glucose and lipid metabolism and insulin sensitivity in lipoprotein lipase gene knoc
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Pancreatic beta cell dysfunction is a central role of developmemt of type 2 diabetes[1].And the chronic dislipidemia (li......
Dietary Fiber Prevents Obesity-related Liver Lipotoxicity in C57BL/6J Mice Fed with a High-fat/Chole
Adequate intake of dietary fibers has proven metabolic and cardiovascular benefits,molecular mechanisms remain poorly un......
糖尿病对脑部结构功能有多方面影响,但糖尿病引发的认知功能障碍却常常被忽视.糖尿病性认知功能障碍的发生机制十分复杂,其中糖脂......
A comparison of the biological activities of ethyl acetate fractions from the stems and leaves of Pe
Penthorum chinense Pursh(PCP)is a popular traditional medicinal plant in China,widely used for the treatment of a variet......
Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disorder in weste countries and it is commonl......
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LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/Fox
Background Pancreatic β cells are susceptible to fatty acid-induced apoptosis.The 17β-estradiol (E2) protects pancreat......
Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Preve
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Relationship between Free Fatty Acid Spectrum, Blood Stasis Score, and Macroangiopathy in Patients w
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
脂毒性可通过抑制β细胞胰-十二指肠同源盒因子-1(PDX-1)和肌腱膜纤维肉瘤癌基因同源核A(MafA)的表达,使胰岛素基因表达减少,并通......
2型糖尿病多合并血脂紊乱.脂毒性可能通过多种途径、多种因素促进β细胞的功能障碍和凋亡,如神经酰胺、蛋白激酶家族、氧化应激、c......
分离SD大鼠胰岛接种于24孔板中,用不同浓度的葡萄糖和白藜芦醇分别培养1 h或24 h,结果表明白藜芦醇孵育大鼠胰岛1 h可呈剂苗依赖地......
LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/Fox
Background Pancreatic β cells are susceptible to fatty acid-induced apoptosis.The 17β-estradiol (E2) protects pancreat......
目的:研究阿魏酸对棕榈酸诱导的HepG2肝细胞脂毒性的保护作用并初步探究其分子机制。方法:采用棕榈酸诱导HepG2肝细胞建立脂毒性模......
非酒精性脂肪性肝病(NAFLD)目前是体检时肝脏生化学指标异常的首要原因,但其发生发展的机制仍不十分明确,尚缺乏有效的治疗方法。......
目的：观察微粒化非诺贝特对高脂饲养自发性高血压大鼠（SHR）脂毒性及胰岛素敏感性（Is）的影响。方法：将27只SHR随机分为3组，1组给予标准饲料......
目的:研究丹酚酸A对棕榈酸诱导的AML12肝细胞脂毒性的保护作用并初步探究其分子机制。方法:采用棕榈酸诱导AML12细胞建立脂毒性模......
目的观察苯扎贝特干预前后肥胖和2型糖尿病大鼠糖脂代谢、胰岛分泌功能的变化以及胰岛β细胞的凋亡情况。方法75只雄性SD大鼠随机......
目的研究抑制自噬对昆仑雪菊水提物抗INS-1胰岛细胞脂毒性损伤的保护作用。方法采用棕榈酸(PA)诱导建立INS-1胰岛细胞脂毒性损伤模......
目的 观察2型糖尿病患者调脂治疗前后胰岛β细胞功能变化.方法 2型糖尿病并高脂血症者,以标准馒头餐试验中空腹C肽,餐后30分钟C肽,......
非胰岛素依赖型糖尿病(non-insulin-dependent diabetes mellitus，NIDDM)的发病机理尚未完全明了，通常认为胰岛素抵抗(insulin resis......
目的：观察不同浓度的葡萄糖对胰岛β细胞脂质含量以及脂肪酸转位酶（CD36）表达的影响。方法：分别以5、10、15、20、253、0 mmol/L葡萄糖......
目的 了解肥胖型2型糖尿病OLETF鼠胰岛β细胞是否存在凋亡及β细胞凋亡与糖尿病发生发展的关系。方法 OLETF及对照鼠LETO各20只，......
2型糖尿病多合并血脂紊乱,典型血脂谱为高三酰甘油血症,接近正常水平的低密度脂蛋白胆固醇,高密度脂蛋白胆固醇水平降低,小而密的......
血脂代谢异常是致动脉粥样硬化的独立危险因素,在胰岛素抵抗的环境下更增加了心脑血管疾病的发病率。血脂异常在代谢综合征中占有......
【目的】观察微粒化非诺贝特对伴高甘油三酯（TG）糖代谢异常患者急性胰岛素分泌反应和胰岛素抵抗的改善作用。【方法】53例入选者为按......
目的研究甘油三酯对胰岛细胞分泌功能的影响.方法体外分离SD大鼠胰岛细胞并进行单层细胞培养,以不同浓度(0、0.5、2.5、5.010.0mmo......
G蛋白偶联受体40是中、长链游离脂肪酸的特异性受体,在脂肪酸对葡萄糖刺激胰岛素分泌的调节中具有重要作用。但GPR40是否参与了脂......
Leptin is an adipokine that has been linked with the cardiovascular complications resulting from obesity such as hyperte......
Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health......
Pathophysiological mechanisms involved in non-alcoholicsteatohepatitis and novel potential therapeut
Non-alcoholic fatty liver disease （NAFLD） is a major healthcare problem and represents the hepatic expression ofthe metabo......
Objective The aim of this study is by observing the number change of islets beta cells in gestational rats exposed to hi......
Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of
Obesity is an excessive accumulation of body fat that may be harmful to health. Today, obesity is a major public health ......
